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Tuesday, 24 April 2018 09:15

Murein

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Murein

Flucloxacillin

Presentation

Murein 500: Each capsule contains Flucloxacillin Sodium BP equivalent to Flucloxacillin 500 mg.

 

Description

Flucloxacillin is a narrow-spectrum antibiotic with considerable activity against the following common Gram-positive organisms:

>>Penicillinase producing Staphylococcus aureus

>>Penicillinase sensitive Staphylococcus aureus

>>ß-haemolytic streptococci (Streptococcus pyogenes)

>>Streptococcus pneumoniae

It has little activity against Gram-negative bacilli. However, the Gram-negative organisms Neisseria gonorrhoeae and Neisseria meningitidis come within the range of activity. Flucloxacillin kills bacteria by inhibiting the formation of cell wall of bacteria.

 

Indications and Uses

>>Skin and Soft Tissue Infections: Boils, abscesses, carbuncles, furunculosis, infected  wounds, infected burns, protection of skin grafts, otitis media and externa, impetigo.

>>Infected Skin Conditions: Ulcer, eczema and acne.

>>Respiratory Tract Infections: Pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, quinsy.

>>Other infections caused by  Flucloxacillin-sensitive organisms such as osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, septicaemia.

 

Flucloxacillin is also indicated for use as a prophylactic agent during major surgical procedures where appropriate, for example, cardiothoracic and orthopaedic surgery.

 

Dosage

Adults (including elderly patients): 

Oral:

500 mg three to four times a day. Oral doses should be administered 1 hour before meal.

 

Children

2-10 years: Half of adult dose.

Under 2 years: One fourth of adult dose.

Children have been given doses of 12.5mg/kg body weight four times a day.

 

Patients with impaired renal function:

As common with other penicillins, Flucloxacillin usage in patients with renal impairment does not usually require dosage reduction. However, in the presence of severe renal failure (creatinine clearance<10 ml/min) a reduction in dose or an extension of dosage interval should be considered.

 

 

 

 

Side effects

There have been some common side effects of GIT such as nausea, vomiting, diarrhoea, dyspepsia and other minor gastrointestinal disturbances. Besides these rashes, urticaria, purpura, fever, interstitial nephritis, hepatitis and cholestatic jaundice have been reported.

 

Contraindications 

Flucloxacillin should not be given to penicillin-hypersensitive patients.

 

Use in pregnancy

Penicillins are generally considered safe for use in pregnancy. Animal studies with Flucloxacillin have shown no teratogenic effect.

 

Use in lactation

Flucloxacillin is excreted in breast milk in trace amounts. Flucloxacillin may be administered during the period of lactation.

 

Overdosage

Although overdosage problems are unlikely to occur with penicillins, and should be treated symptomatically.

 

Commercial Pack

Murein 500: Each box contains 7 strips of 4 capsules.

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